Understanding molecular mechanisms of host-microbial crosstalk in diseases
Developing novel approaches for therapeutic manipulation of microbiome
Developing new software for microbiome data analysis
Microbiome Systems Biology research group investigates how our health and diseases are influenced by our gut microbiome. Our research is interdisciplinary, combining metagenomics (a technique to study gut microbiome), genomics, genetics, (meta)transcriptomics, and metabolomics to study host-microbial cross-talk.
Obesity, diabetes and several other metabolic disorders are increasing at an alarming rate across the globe. Although lifestyle changes and lack of physical activity are widely being blamed for this trend, the true cause for these diseases is more likely the interactions between human genetics, environmental factors and the human microbiome. For the past several years, researchers around the world have only been focusing on the interactions between two of these three factors, and ignoring the microbiome. The human gut microbiome plays an important role in our health, nutrition and well-being. Its imbalance may signify an unhealthy state of the host (like in Inflammatory Bowel Diseases), or worse, might be the reason for an ailment (like in Clostridium difficile infections). We aim to study the interactions between all three factors – human genetics, environmental factors and human microbiome – in order to understand the molecular mechanisms underlying metabolic disorders.
Our current externally funded studies investigate the role of gut microbiome in multiple sclerosis (Lundbeck Foundation), obesity (Novo Nordisk Foundation), alcoholic liver fibrosis (EU Horizon 2020), ageing (Danish Independent Research Council) and producing antimicrobial peptides (Danish Independent Research Council). We have ongoing international collaborations studying the interaction between the gut microbiome and the host in the context of several diseases, including cardiometabolic diseases, chronic liver diseases and cancer.
We study the host-microbial cross-talk in liver fibrosis as partners in the GALAXY and MicrobLiver consortia. We characterize the total gut microbiome consisting of bacteria, archaea, fungi and viruses to study it as one large community. We integrate genetics, metabolomics, proteomics and metatranscriptomics as additional layers to model the human-microbial holobiont.
We recently published on discovering robust biomarkers for colorectal cancer from the gut microbiome. We successfully validated them using qPCR measurements in an independent cohort. We are currently working on a meta-analysis of colorectal cancer microbiome studies.
We use bioinformatic approaches to discover bioactive molecules from the microbiome, for example antibiotics.
We investigate the gut microbiome in inflammation and aging (termed Inflammaging) as part of the Marie Curie Fellowship to post-doc Thorsten Brach.
We use a spontaneous EAE mouse model to investigate the role of gut microbiome in the development of multiple sclerosis. This is a collaboration with Max-Planck Institute.